Listed on the Australian Register of Therapeutic Goods (ARTG) with AUST L 377284 and manufactured in accordance with the TGA’s guidelines for listed medicines, ensuring it meets stringent Australian quality and safety standards.
One of the oldest spices known to man, saffron has been used in traditional Chinese and Ayurvedic medicine for centuries to help relax the nervous system. Affron® is the world's most published saffron extract with superior quality. It has been shown to support mood, stress resilience, and sleep through serotonin- and dopamine-mediated effects. It has been shown to reduce irritability, emotional swings, and nighttime anxiety, often improving overall wellbeing within weeks. Not a primary hot-flush treatment but helps women manage the psychological and sleep challenges common during perimenopause.
- A double-blind, placebo-controlled study showed that perimenopausal women taking Affron® for 12 weeks experienced a reduction of 32-33% in low mood and occasional stress, without undesirable estrogenic effects.
- In a randomised, double-blind, placebo-controlled study affron® intake for 4 weeks showed signs of improved mood and alleviated stress or tension related anxieties and associated fatigue. The affron® intake was well tolerated and no associated side effects were noted.
- In a randomised, double-blind, placebo-controlled study, of men and women aged between 18 and 70 years, affron® supplementation was associated with greater improvements in sleep quality - with restorative sleep increasing by 20% - as well as an improvement in mood after awakening.
The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. Lopresti A. L., Smith S. J. J Menopausal Med. 2021 Aug;27(2):66-78
affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomised, placebo-controlled clinical trial . Kell G, et al. Complement Ther Med. 2017 Aug;33:58-64.
New clinical evidence of affron® efficacy as an adjunct treatment for unremitted depression. Lopresti AL, et al. J Psychopharmacol. 2019. Nov;33(11):1415-1427.
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo- controlled study. Lopresti AL, et al. J Affect Disord. 2017 Jan 1;207:188-196.
Sleep enhancement by saffron extract in randomised control trial, Japanese Pharmacology and Therapeutics. Nishide, A, et al. Japanese Pharmacology and Therapeutics. 2018 (8); 46:1407-1415.
affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Lopresti AL, et al. J Affect Disord. 2018 May;232:349-357.
Fenugreek has been used as a medicinal plant in traditional Chinese and Ayurvedic medicine for centuries to support reproductive health. TESTOFEN® is the world's most clinically-researched fenugreek seed extract. It has been shown to support sexual health and the symptoms - daytime hot flushes and night sweats - associated with perimenopause and menopause.
- A double-blind, randomized, placebo-controlled trial that recruited 115 healthy women aged 40 to 65 years, over a 12 week period. There was a significant reduction in menopausal symptoms in the active group compared with placebo. The active group reporting significantly less daytime hot flushes and night sweats at 12 weeks. This study demonstrated that this proprietary fenugreek seed extract may reduce menopausal symptoms in healthy women.
Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study E Steels 1, M L Steele 2 3, M Harold 4, S Coulson 1
Ashwagandha has been called the king of Ayurvedic herbs and is most widely used for reducing stress and anxiety. KSM-66® is the most extensively clinically studied ashwagandha root extract in the world.
- A double-blind, randomized, placebo-controlled trial involving 60 stressed healthy men and women over an 8 week period showed significant reduction in stress with serum cortisol levels decreasing as well as significant improvement in sleep.
Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Salve, J., et al., (2019).Cureus, 11(12), e6466.
Safety of 12-months administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study. Salve, J., et al (2025). Phytotherapy Research 1–11
Panax ginseng root extract is one of the most popular herbal medicines and has been used in Traditional Chinese Medicine for hundreds of years. It has been shown to be helpful with relieving physical fatigue, improving stamina, energy and endurance. Furthermore, long term consumption of Korean Ginseng may be beneficial to cognitive function in late life.
Coleus is an Ayurvedic herb that has been used for centuries as a traditional remedy. It is renowned for supporting thyroid and cardiovascular system function. From an Ayurvedic perspective it is renowned for balancing all three doshas. One of the central concepts in Ayurvedic Medicine is that the Doshas govern all aspects of our physical and mental health.
Tribulus has been used in Traditional Ayurvedic and Chinese Medicine for centuries as an aphrodisiac, to enhance and promote a healthy libido as well as supporting the health and function of the reproductive system.
Cinnamon verum or 'true cinnamon' has been used for centuries in traditional medicine to support healthy blood sugar levels in the body. Cinnamon is a source of antioxidants helping protect against free radical damage. It has also been used in Traditional Ayurvedic and Chinese Medicine as a circulatory and digestive tonic.
The history of rosemary in herbal medicine dates back centuries. Rosemary is traditionally used in Western Herbal Medicine to support healthy memory and mood. Modern science today, reveals that the power of rosemary resides primarily in it's unique antioxidants, which reduces free radicals formed in the body.
Zinc is critical for reproductive hormone regulation, connective tissue health, and skin health. Zinc also supports both a healthy sexual function and libido. Zinc and Selenium are precursor nutrients for the synthesis of the catecholamines dopamine, epinephrine and norepinephrine, and the thyroid hormone thyroxine.
Selenium supports healthy reproductive hormones, thyroid function, cardiovascular health, and antioxidant defense mechanisms. It is an essential micromineral and antioxidant used by the body to help prevent free radical oxidative damage to cells. Zinc and Selenium are precursor nutrients for the synthesis of the catecholamines dopamine, epinephrine and norepinephrine, and the thyroid hormone thyroxine.
